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Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder in Patients with Myelodysplastic Syndromes

2018-08-09

ZHAO Pan, LIANG Jun-bin, DENG Zhong-yang, WANG Ming-jing,
   QIN Jia-yue, CHEN Chong-jian, et al    


摘要:

Objectives:To investigate the relationship between gene mutations and response to Compound Qinghuang Powder (复方青黄散, CQHP) in patients with myelodysplastic syndrome (MDS).

Methods:Forty-three MDS patients were genotyped by ultra-deep targeted sequencing and the clinical data of patients were collected and the relationship between them was analyzed.

Results:Up to 41.86% of patients harbored genet mutations, in most cases with more than one mutation. The most common mutations were in SF3B1, U2AF1, ASXL1, and DNMT3A. After treatment with CQHP, about 88.00% of patients no longer required blood transfusion, or needed half of prior transfusions.

Conclusions:CQHP is an effective treatment for patients with MDS, especially those with gene mutations in SF3B1, DNMT3A, U2AF1, and/or ASXL1.


文章链接:

https://link.springer.com/article/10.1007%2Fs11655-018-2977-3


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Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder in Patients with Myelodysplastic Syndromes-基因组-平台实力-安诺优达
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